{"id":2596,"date":"2025-10-06T18:28:17","date_gmt":"2025-10-06T15:28:17","guid":{"rendered":"https:\/\/thesciencesupport.com\/?p=2596"},"modified":"2025-10-06T18:33:36","modified_gmt":"2025-10-06T15:33:36","slug":"revvitys-ivd-solutions-for-hemoglobinopathies","status":"publish","type":"post","link":"https:\/\/thesciencesupport.com\/en\/revvitys-ivd-solutions-for-hemoglobinopathies\/","title":{"rendered":"Revvity&#8217;s IVD Solutions for Hemoglobinopathies: Why Early Detection Matters"},"content":{"rendered":"<p>Hemoglobinopathies such as sickle cell disease and \u03b2-thalassemia are among the most common inherited blood disorders worldwide. For countries like Greece and across the Mediterranean, where these conditions are still highly prevalent, early detection and prevention are critical to reducing disease burden and improving quality of life.<\/p>\n<p>At <strong>The Science Support<\/strong>, we work with leading partners such as <a href=\"https:\/\/www.revvity.com\/?utm_source=chatgpt.com\"><strong>Revvity<\/strong><\/a> to bring laboratories reliable, high-performance in vitro diagnostic (IVD) solutions designed to detect hemoglobinopathies accurately and efficiently \u2014 from newborn screening to parental carrier testing.<\/p>\n<h3><strong>Why Early Detection of Hemoglobinopathies Matters<\/strong><\/h3>\n<p>Early diagnosis of <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ijlh.13885\"><strong>hemoglobinopathies<\/strong><\/a> is not only about identifying disease \u2014 it\u2019s about enabling timely intervention, prevention, and informed decision-making for families.<\/p>\n<p><strong>For Newborns:\u00a0<\/strong>Newborns with hemoglobin disorders often show no immediate symptoms due to high levels of fetal hemoglobin (Hb F), which can mask the presence of pathological variants. Early screening enables timely detection of sickle cell anemia and \u03b2-thalassemia major, ensuring appropriate monitoring and treatment from the start.<\/p>\n<p><strong>For Parents:\u00a0<\/strong>Carrier detection helps identify individuals at risk of passing on the disease to their children. Integrating carrier testing into genetic counseling and family planning programs supports prevention and reduces disease prevalence in future generations.<\/p>\n<p>Revvity\u2019s <a href=\"https:\/\/www.revvity.com\/product\/resolve-hemoglobin-kit-fr-9120\"><strong>RESOLVE\u2122 Hemoglobin Kit<\/strong><\/a> used together with the <a href=\"https:\/\/www.revvity.com\/product\/migeletm-gel-electrophoresis-unit-gener-2118-0020\"><strong>Migele\u2122 Electrophoresis Unit<\/strong><\/a> provides laboratories with a <strong>r<\/strong>obust, scalable platform for hemoglobin variant analysis.<\/p>\n<ul>\n<li><strong>Flexible Sample Formats: <\/strong>Compatible with whole blood, cord blood, or dried blood spots (DBS)<span style=\"color: #555555; font-size: 14.4px;\">, this system is ideal for both <\/span>routine diagnostics<span style=\"color: #555555; font-size: 14.4px;\"> and <\/span>large-scale newborn screening programs.<\/li>\n<\/ul>\n<ul>\n<li><strong>High Specificity and Sensitivity: <\/strong>Using <a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/isoelectric-focusing\"><strong style=\"color: #555555; font-size: 14.4px;\">Isoelectric Focusing (IEF) <\/strong><\/a>, the system achieves superior separation and resolution of clinically relevant hemoglobins, allowing precise differentiation between variants.<\/li>\n<\/ul>\n<p>Key advantages include:<\/p>\n<ul>\n<li>Clear distinction of Hb F from Hb A, differentiating sickle cell anemia (Hb SS) from sickle cell trait (Hb AS).<\/li>\n<li>Accurate separation of Hb C, Hb A2, and Hb E, as well as rare forms such as Hb D-Los Angeles, Hb G-Philadelphia, and Hb Lepore from Hb S.<\/li>\n<li>Detection of minor variants such as Hb Bart\u2019s in newborns and Hb Constant Spring in adults.<\/li>\n<li>Scalable, Fast Workflow: With results available in 60\u201390 minutes, laboratories can achieve high throughput without compromising precision. Multiple Migele\u2122 units can run in parallel using a single water bath, while the JB-2 staining system enhances visibility and interpretability of hemoglobin bands.<span style=\"color: #555555; font-size: 14.4px;\">\u00a0<\/span><\/li>\n<\/ul>\n<h3><strong>Real-World Impact for Families<\/strong><\/h3>\n<p>In Greece, \u03b2-thalassemia continues to affect many families, making reliable hemoglobinopathy screening an essential part of national healthcare programs. By enabling accurate detection at both the newborn and parental levels, Revvity\u2019s RESOLVE\u2122 + Migele\u2122 solution supports early intervention, prevention, and informed reproductive choices \u2014 helping to reduce disease transmission and improve long-term outcomes.<\/p>\n<h3><strong>A Partnership for Diagnostic Laboratories<\/strong><\/h3>\n<p>At <strong>The Science Support<\/strong>, we are proud to deliver Revvity\u2019s proven technologies to diagnostic laboratories \u2014 combining innovation, accessibility, and precision to advance hemoglobinopathy detection and prevention.<\/p>\n<p>Contact us at sales@thesciencesupport.com to discuss how you can integrate Revvity\u2019s RESOLVE\u2122 + Migele\u2122 IVD systems into your laboratory workflow for best results. Find out more about <a href=\"https:\/\/thesciencesupport.com\/en\/applications-and-suppliers\/preimplantation-non-%ce%b9nvasive-prenatal-neonatal-testing\/\"><strong>our complete portfolio<\/strong><\/a> of solutions for advanced and early detection of crucial disorders in newborn screening.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>References<\/strong><\/p>\n<ol>\n<li>Revvity Hemoglobinopathy Screening Solutions<\/li>\n<li>Weatherall, D. J., &amp; Clegg, J. B. (2001). <em>The Thalassaemia Syndromes<\/em>. Blackwell Science.<\/li>\n<li>Modell, B., &amp; Darlison, M. (2008). <em>Global epidemiology of haemoglobin disorders and derived service indicators<\/em>. Bulletin of the World Health Organization, 86(6), 480\u2013487.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>At The Science Support, we work with leading partners such as Revvity to bring laboratories reliable, high-performance in vitro diagnostic (IVD) solutions designed to detect hemoglobinopathies accurately and efficiently \u2014 from newborn screening to parental carrier testing. Learn more.<\/p>\n","protected":false},"author":3,"featured_media":2597,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[10,9],"tags":[],"class_list":["post-2596","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-news-events"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Revvity&#039;s IVD Solutions for Hemoglobinopathies: Why Early Detection Matters - The Science Support<\/title>\n<meta name=\"description\" content=\"At The Science Support, we are proud to deliver Revvity\u2019s RESOLVE\u2122 + Migele\u2122 solution to support early detection of hemoglobinopathies.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/thesciencesupport.com\/en\/revvitys-ivd-solutions-for-hemoglobinopathies\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Revvity&#039;s IVD Solutions for Hemoglobinopathies: Why Early Detection Matters - 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